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What JARDIANCE Is Used For?

In addition to lowering blood sugar, Jardiance can also lower your A1C levels (the percentage of hemoglobin molecules in your blood that have glucose molecules attached to them).

The medication was approved by the Food and Drug Administration (FDA) in 2014.

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The FDA approval was based on the results from more than 10 multinational clinical trials involving more than 13,000 people with type 2 diabetes.

Boehringer Ingelheim Pharmaceuticals, Inc. and Eli Lilly and Company manufacture Jardiance.


Empagliflozin belongs to the class of medications called oral antihyperglycemic agents. It works in the kidneys to increase the amount of glucose removed from the body by the kidneys.

Empagliflozin is used alone or in combination with other medications for people with type 2 diabetes to control their blood glucose. This medication should be used as part of an overall diabetes management plan that includes a diet and exercise program.

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Empagliflozin is also used for people with type 2 diabetes who also have cardiovascular disease. It is used in addition to diet, exercise and other medications to reduce the risk of dying from cardiac disease.


Common Side Effects of Jardiance

Tell your doctor if any of the following side effects become severe or don’t go away:

  • Increased thirst
  • Frequent urination (including at nighttime)

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Serious Side Effects of Jardiance

Call your doctor immediately if you experience any of the following serious side effects:

  • Painful, frequent, or burning urination
  • Urine that looks cloudy
  • Back or pelvic pain
  • Nausea
  • Confusion
  • Vaginal odor, white or yellowish vaginal discharge, or vaginal itching
  • Redness, itching, or swelling of the penis; rash on the penis; pain on the skin around the penis; or foul-smelling discharge from the penis
  • Flu-like symptoms
  • Symptoms of an allergic reaction (anaphylaxis), which may include skin rash, hives, or swelling of the face, lips, tongue, or throat

Jardiance Kidney Failure Risk

SGLT2 inhibitors like Jardiance work in a different way than other diabetes drugs, impacting the normal function of the kidney to increase the amount of sugar excreted in the urine. This was designed to increase glucose production and lower blood glucose levels among diabetics. However, it may be the cause of Jardiance kidney problems.

Adverse event reports submitted on behalf of users of the similar type 2 diabetes drug Invokana suggest that users may face a risk of kidney toxicity from Jardiance, which users of this class of medications reporting a high number of cases involving:

  • Kidney Failure
  • Kidney Impairment
  • Kidney Stones
  • Urinary Tract Infections
  • Abnormal Weight Loss
  • Hypersensitivity Reactions

Latest JARDIANCE News & Recalls

The U.S. Food and Drug Administration is warning doctors and patients that some widely used diabetes drugs may, in some rare cases, cause a flesh-eating bacterial infection of the genitals. The condition, known as Fournier’s gangrene, developed in a dozen patients shortly after they began taking the medicines between March 2013 and May 2018, the FDA said. The seven men and five women were all hospitalized and underwent surgery for the condition. One patient died.

Lawsuits & Settlements

In late August 2018 the FDA warned doctors and patients that cases of Fournier’s gangrene, a rare but serious infection of the genitals and area around the genitals, have been reported with the class of type 2 diabetes medicines called sodium-glucose cotransporter-2 (SGLT2) inhibitors. More specifically, this serious rare infection is called necrotizing fasciitis of the perineum.

Oral diabetes medicines included in this SGLT2 inhibitors drug class are Invokana, Farxiga, and Jardiance, as well as Invokamet, Xigduo, Glyxambi, Synjardy, Qtern, Steglatro, Steglujan, and Segluromet.

From this August 29, 2018 Drug Safety Communication, “FDA warns about rare occurrences of a serious infection of the genital area with SGLT2 inhibitors for diabetes“, we get the following details about this new safety issue for Invokana, Farxiga, Jardiance, and the other SGLT2 inhibitor diabetes drugs, including Jardiance.